System analysis of bacterial signaling.
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System analysis of bacterial signaling.

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Published .
Written in English

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A system analysis of the Competence Stimulating Peptide (CSP) quorum-sensing pathway of Streptococcus mutans is presented. A stochastic model of the pathway was developed. This model successfully reproduces experimental mRNA profiles. The pathway was then decomposed into transmitting and receiving sections. Stochastic models of these sections were studied to estimate the statistical distributions of their outputs. The transmitting section was used to construct a transmitter cell using the multiple sugar metabolism promoter from S. mutans to drive the production of the CSP signaling molecules. This is the first reported inducible promoter used to regulate the expression of a cloned gene in S. mutans. Previously, the CSP receiving section was used to construct a receiver cell that responds to CSP by producing beta-galactosidase. Preliminary results showed a two-fold signal increase lasting for five minutes when the receiver was exposed to the supernatant containing CSP from the transmitter.

The Physical Object
Pagination103 leaves.
Number of Pages103
ID Numbers
Open LibraryOL19747557M
ISBN 100612914674

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This book blends information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signaling, and gene expression control with well-known gene regulation paradigms from model organisms (including pathogens) to give readers a picture of how information flows from the environment to the gene.   In biology, cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. A signal is an entity that codes or conveys ical processes are complex molecular interactions that involve a lot of signals. The ability of cells to perceive and correctly respond to their.   Two-component systems (TCS) are ubiquitous among bacteria. They play essential roles in signaling events in bacteria, such as cell-cell communication, adaptation to environments, and pathogenesis in the case of pathogens. Due to their absence in humans and other mammals, TCS proteins are considered potential targets for developing new by: Certain bacteria can produce enzymes called lactonases that can target and inactivate AHLs. Researchers have developed novel molecules which block the signalling receptors of bacteria (Quorum quenching). mBTL is a compound that has been shown to inhibit quorum sensing and decrease the amount of cell death by a significant amount.

Paracrine signaling acts on nearby cells, endocrine signaling uses the circulatory system to transport ligands, and autocrine signaling acts on the signaling cell. Signaling via gap junctions involves signaling molecules moving directly between adjacent cells. Other forms of signaling not shown include neural, neuroendocrine, and pheremones. This book was conceived and organized as an instructional resource to introduce advanced students, investigators new to the field, and even researchers actively working in this general area to the underlying foundations and basic mechanisms of signal transduction in animal cells. Such a volume is needed because signaling impinges on every. Another book to read is Linear Signals and systems by Lathi. Do not go for Simon Haykin. It is not for beginners. This is the best book in the area of signals and systems. This book is strongly recommended and added as a reference by IITs, NITs and various MOOCs for signals and Systems. I find this book very easy to understand and quite good.   In this study, we tested the hypothesis that the conserved bacterial Rcs stress response system mediates corneal pathogenesis associated with Serratia marcescensocular infections. This was accomplished by modifying Rcs activity using mutant strains. These include a mutant that has a hyper-active Rcs system due to deletion of the IgaA family gene,gumB, and a gumB rcsCdouble mutant that .

  One major role of bacterial extracellular small-molecule signaling is in cell-cell communication (quorum sensing), which involves the production, release, and community-wide detection of molecules called autoinducers ().Quorum sensing provides a mechanism for bacteria to monitor one another’s presence and to modulate gene expression in response to changes in population density. When the population density of the bacteria reached a certain level, specific gene expression was initiated: the bacteria produced bioluminescent proteins that emitted light. Because the number of cells present in the environment (the cell density) is the determining factor for signaling, bacterial signaling was named quorum sensing.   Cyclic AMP, one of the earliest discovered and most intensely studied signalling molecules in molecular biology, is widely believed to be focused on carbon metabolism in bacteria. Bacterial quorum sensing (QS) is a cell-to-cell communication phenomenon that allows bacteria to control the expression of certain specialized genes depending on their cell population size. Signaling molecules such N-acylhomoserine lactones (AHLs) mediate the communication, and their concentration reflects the bacterial population density.